Sickle Cell Disease
People with Sickle Cell Disease are asked to participate in a research study being conducted by Montefiore Medical Center.
You may be eligible to participate in this study if you:
• Are a male or female at aged 8 to < 18 years
• Have confirmed diagnosis of SCD (all genotypes)
• Are receiving erythropoiesis-stimulating agents (ESAs) you must have been on a stable dose for at least 12 weeks before enrollment with no dose modifications planned or anticipated by the Investigator
• Are receiving HU, you must have been on a stable dose for at least 90 days
prior to signing the ICF/AF, with no dose modifications or initiation of HU planned or anticipated by the Investigator
You may NOT participate in this study if you:
• Have had RBC transfusion within 3 months before initiation of study drug or receive scheduled RBC transfusion therapy
• Have history of overt stroke
• Have congenital brain malformation
• Have had surgery within 8 weeks before Day 1
• Have anemia due to bone marrow failure
• Have Severe renal dysfunction
• Have clinically significant bacterial, fungal, parasitic, or viral infection
• Have symptomatic COVID-19 infection
• Are pregnant or breastfeeding
Contact Information
Karen Ireland, Study Coordinator
111 E. 210th Street Bronx, NY 10467
Phone: (718) 741-2401
Email: kireland@montefiore.org
21-10-435