Voxelotor Cerebral Hemodynamics Study
People with Sickle Cell Disease are asked to participate in a research study being conducted by Montefiore Medical Center.
You may be eligible to participate in this study if you:
• Are a male or female aged 12 to 30 years
• Have confirmed diagnosis of Sickle Cell Disease with HbSS or Hbβ0 thalassemia genotype
• If receiving erythropoiesis-stimulating agents (ESAs), must have been on a stable dose for at least 12 weeks before enrollment with no dose modifications planned or anticipated
• If receiving HU, they must have been on a stable dose for at least 90 days prior to signing the Informed Consent Form/Assent Form
You may NOT be eligible to participate in this study if you:
• Have history of overt stroke including hemorrhagic stroke, transient ischemic attacks, or spinal cord injury
• Have non-MRI compatible metal hardware and/or metal braces
• Are taking or has received crizanlizumab (Adakveo®) within 90 days prior to the Screening Visit
• Have had surgery within past 8 weeks
• Have anemia due to bone marrow failure
• Have history of hematopoietic stem cell transplant or gene therapy
• Have a clinically significant bacterial, fungal, parasitic, or viral infection which requires therapy
• Have symptomatic COVID-19 infection
• Are pregnant or breastfeeding
Contact Information
Jennifer De Los Santos, Study Coordinator
111 E. 210th Street Bronx, NY 10467
Phone: (718) 741-2672
Email: JENNIFER.DELOSSANTOS@EINSTEINMED.ORG
21-10-436