Solid Tumors

People with solid tumors are asked to participate in a research study being conducted by Montefiore Medical Center.

You may be eligible to participate in this study if you:

  • Are a male or female at least 18 years of age
  • Have treated brain metastases
  • Have NSCLC
  • Agree to provide tumor tissue

You may NOT participate in this study if you:

  • Have received investigational treatment in another clinical study within the past 3 weeks
  • Have history of severe allergy or anaphylactic reaction to previous monoclonal antibodies
  • Have clinically significant iron metabolism disorders
  • Have serious concurrent illness
  • Are pregnant or breastfeeding

Contact Information
Charlotte Sklow, Study Coordinator
111 Esat 210th Street, Bronx, New York, 10467
Phone: 718-405-8535
Email: charlotte.sklow@einsteinmed.org

 

Advanced Solid Tumors with KRAS G12C Mutation

People with Advanced Solid Tumors with KRAS G12C Mutation are asked to participate in a research study being conducted by Monter Cancer Center.

You may be eligible to participate in this study if you:
• Are a male or female at least 18 years of age
• Have histologically confirmed diagnosis of a solid tumor malignancy
• Have presence of tumor lesions

You may NOT participate in this study if you:
• Have active brain metastases
• Have undergone major surgery within 4 weeks of first dose date
• Have carcinomatous meningitis
• Have a history of stroke or transient ischemic attack
• Have known immunodeficiency virus (HIV) infection, hepatitis B, or C
• Are pregnant or breastfeeding

Contact Information
Alexa Amoroso, Study Coordinator
450 Lakeville Road, Lake Success, NY 11042
Phone: (516) 734-8977
Email: AAMOROSO1@NORTHWELL.EDU

HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR 2 (HER2) POSITIVE AND NEGATIVE SOLID

People with solid tumors are asked to participate in a research study being conducted by Monter Cancer Center.

You may be eligible to participate in this study if you:
• Are a male or female at least 18 years of age
• Have adequate bone marrow, liver, & renal function
• Are able provide a fresh biopsy sample
• Have documentation of histologically or cytologically confirmed diagnosis of HER2 IHC 1+ or IHC 2+/ISH- BC

You may NOT participate in this study if you:

• Have history of prior malignancy other than the diseases under study within the past 5 years
• Have had major surgery within 4 weeks prior to registration.
• Are pregnant or breastfeeding
• Have serious pulmonary illness
• Have an active inflammatory bowel disease, chronic diarrhea, short bowel syndrome, or any upper gastrointestinal surgery including gastric resection
• Have a history of, or ongoing, corneal disorder
• Have an active and clinically significant bacterial, fungal, or viral infection
• Have a history or active interstitial lung disease, pulmonary fibrosis, or a history of other clinically significant lung diseases.

Contact Information
Melissa Ramgadoo, Study Coordinator
450 Lakeville Road, Lake Success, New York 11042
Phone: (516) 734-8839
Email: mramgadoo@northwell.edu

PRA Partnership-Solid Tumors and Lymphomas

People with Solid Tumors and Lymphomas are asked to participate in a research study being conducted by Monter Cancer Center.

You may be eligible to participate in this study if you:
• Are a male or female at least 18 years of age
• Have histologically or cytologically confirmed advanced solid tumors or lymphoma that is metastatic or unresectable
• Have acceptable organ function

You may NOT participate in this study if you:
• Have hypersensitivity to ASTX660
• Have poor medical risk because of systemic diseases
• Have a history of, or at risk for, cardiac disease
• Have a known history of human immunodeficiency virus (HIV) infection, hepatitis B or C
• Have had prior anticancer treatments or therapies within the indicated time window prior to first dose of study treatment (ASTX660)
• Have known brain metastases unless stable or previously treated
• Are pregnant or breastfeeding

Contact Information
Carolyn Pellizzari, Study Coordinator
450 Lakeville Road, Lake Success, NY 11042
Phone: (516) 734-8921
Fax: 516-734-8909
Email: cpellizzar@northwell.edu

Advanced Solid Tumor Malignancies

Trial Name: BGB-A1217/BGB-A317 Phase 1/1b Study Investigating Safety, Tolerability,
Pharmacokinetics and Preliminary Antitumor Activity of Anti-TIGIT Monoclonal Antibody BGB-A1217 in Combination with Anti-PD-1 Monoclonal Antibody Tislelizumab (BGB-A317) in Patients with Unresectable Locally Advanced or Metastatic Solid Tumors

People with Advanced Solid Tumor Malignancies are asked to participate in a research study being conducted by Montefiore Medical Center.

You may be eligible to participate in this study if you:
• Are a male or female at least 18 years of age
• Have histologically or cytologically confirmed unresectable locally advanced or metastatic solid tumors
• Have adequate organ function
• Have histologically or cytologically confirmed extensive-stage SCLC with no prior systemic therapy
• Have archived tumor tissue or fresh biopsy

You may NOT participate in this study if you:
• Have active leptomeningeal disease or uncontrolled brain metastasis
• Have any active malignancy
• Have history of interstitial lung disease, noninfectious pneumonitis, or uncontrolled lung diseases
• Have known immunodeficiency virus (HIV) infection, hepatitis B or C
• Had major surgery (<3 weeks prior to the first dose of study drugs) • Are pregnant or breastfeeding Contact Information Cristal Garcia, Study Coordinator 1695 Eastchester Road – Bronx, NY 10461 Phone: (718) 405-8477 Fax: (718) 405-8230 Email: crigarci@montefiore.org

TALAZOPARIB SOFT GEL CAPSULE FORMULATION Advanced Solid Tumors

People with Advanced Solid Tumors are asked to participate in a research study being conducted by Montefiore Medical Center.

You may be eligible to participate in this study if you:
• Are a male or female between the ages of 18 and 70
• Have histological diagnosis of recurrent, locally advanced or metastatic solid tumor
• Have adequate bone marrow, renal, and hepatic function
• Are able to swallow capsules whole without breaking apart or crushing

You may NOT participate in this study if you:
• Have had major surgery within the past 4 weeks
• Have been diagnosed with MDS or AML
• Have an active infection
• Have known or suspected brain metastasis or active leptomeningeal disease
• Have clinically significant cardiovascular disease
• Have known history of testing positive for HIV, AIDS, positive HBV surface antigen, positive HCV RNA, or positive COVID-19 viral test
• Are pregnant or breastfeeding

Contact Information
Mohammad Ghalib, Study Coordinator
1695 Eastchester Road, 2nd floor
Bronx, NY 10461
Phone: (718) 405-8515
Email: mhghalib@montefiore.org

Solid Tumors with KRAS p.G12C Mutation

People with Solid Tumor are asked to participate in a research study being conducted by Montefiore Medical Center.

You may be eligible to participate in this study if you:
• Are a male or female at least 18 years of age
• Are willing to provide tumor tissue samples
• Have the ability to take oral medications
• Pathologically documented, locally-advanced or metastatic malignancy with KRAS

You may NOT participate in this study if you:
• Have a history of malignancy within the past 2 years
• Have an active infection requiring IV antibiotics
• Have gastrointestinal tract disease causing inability to take oral medications
• Have known immunodeficiency virus (HIV) infection, hepatitis B, or hepatitis C
• Are pregnant or breastfeeding

Contact Information
Mohammad Ghalib, Study Coordinator
1695 Eastchester Road, 2nd floor
Bronx, NY 10461
Phone: (718) 405-8515
Email: mhghalib@montefiore.org

Sym021 in Combination with Either Sym022 or Sym023 in Patients with Advanced Solid Tumor Malignancies

People with Advanced Solid Tumor Malignancies are asked to participate in a research study being conducted by Montefiore Medical Center.

You may be eligible to participate in this study if you:

• Are a male or female at least 18 years of age
• Have documented (histologically or cytologically proven) unresectable, locally advanced or metastatic malignancies
• Have adequate organ function

You may NOT participate in this study if you:

• Have Central Nervous System unless treated and stable malignancies
• Have a significant cardiovascular disease, recent gastrointestinal disease, or pulmonary disease
• Have a history of organ transplant
• Have known immunodeficiency virus (HIV) infection, hepatitis B, or hepatitis C
• Are pregnant or breastfeeding

Contact Information
Mohammad Ghalib, Study Coordinator
1695 Eastchester Road, 2nd floor
Bronx, NY 10461
Phone: (718) 405-8515
Email: MHGHALIB@MONTEFIORE.ORG

Metastatic Solid Tumors

People with Metastatic Solid Tumors are asked to participate in a research study being conducted by Montefiore Medical Center.

You may be eligible to participate in this study if you:

• Are a male or female at least 18 years of age
• Have a histologically or cytologically documented, advanced (metastatic and/or unresectable) cancer
• Demonstrate adequate organ function

You may NOT participate in this study if you:

• Have received treatment with systemic anticancer treatments or investigational products (IPs) within 14 days before the first dose of study drug
• Have a history of uncontrolled brain metastasis
• Have had prior treatment with TAK-981
• Have a receipt of any live vaccine
• Have an active infection
• Have known immunodeficiency virus (HIV) infection, hepatitis B or C
• Are pregnant or breastfeeding

Contact Information
Mohammad Ghalib, Study Coordinator
1695 Eastchester Road, 2nd floor
Bronx, NY 10461
Phone: (718) 405-8515
Email: mhghalib@montefiore.org

Phase 1 – Solid Tumors

People with solid tumors are asked to participate in a research study being conducted by Montefiore Medical Center.

You may be eligible to participate in this study if you:

  • Are a male or female at least 18 years of age
  • Have histologically or cytologically documented, locally-advanced or metastatic solid tumors
  • Have adequate kidney function
  • Have archived tumor biopsy available

You may NOT participate in this study if you:

  • Have a preexisting autoimmune disease, heart disease, or rapidly progressive disease
  • Have known immunodeficiency virus (HIV) infection, hepatitis B, or hepatitis C
  • Have serious cardiac illness
  • Have known alcohol or drug abuse
  • Are pregnant or breastfeeding

Contact Information
Mohammad Ghalib, Study Coordinator
1695 Eastchester Road, 2nd Floor
Bronx, New York 10461
Phone: (718) 405-8515
Email: mhghalib@montefiore.org

Advanced and Recurrent Solid Tumors

People with solid tumors are asked to participate in a research study being conducted by Montefiore Medical Center.

You may be eligible to participate in this study if you:

  • Are a male or female at least 18 years of age
  • Have advanced or metastatic solid tumors and have completed first line therapy.
  • Evidence of disease progression
  • Adequate organ function

You may NOT participate in this study if you:

  • Have received chemotherapy within 28 days of the start of study
  • Have an active infection
  • Have known immunodeficiency virus (HIV) infection, hepatitis B, or hepatitis C
  • Are pregnant or breastfeeding

Contact Information
Cristal Garcia, Study Coordinator
1695 Eastchester Rd. Bronx, NY 10461
Phone: (718)- 405-8477
Email: crigarci@montefiore.org

Subjects with Solid Tumors

People with Solid Tumors are asked to participate in a research study being conducted by Montefiore Medical Center.

You may be eligible to participate in this study if you:

  • Are a male or female at least 18 years of age
  • Have adequate organ function
  • Have fresh and/or archival tumor tissue

You may NOT participate in this study if you:

  • Received cancer treatment or live vaccine within 28 days prior to first dose
  • Had major surgery, still unhealed, within 28 days prior to first dose
  • History of lung disease or pneumonia
  • Have known history of autoimmune disease
  • Have known immunodeficiency virus (HIV) infection
  • Are pregnant or breastfeeding

Contact Information
Mohammad Ghalib, Study Coordinator
111 E. 210th Street
Bronx, New York 10467
Telephone:718-405-8515
Email: mhghalib@montefiore.org

Advanced EGFR-positive Solid Tumor Malignancies

People with tumors are asked to participate in a research study being conducted by Montefiore Medical Center.

You may be eligible to participate in this study if you:

  • Are a male or female at least 18 years of age
  • Have a confirmed solid tumor
  • Have archival tumor tissue available

You may NOT participate in this study if you:

  • Have received major surgery within the past 4 weeks
  • Have cardiovascular disease
  • Have significant infections
  • Have known immunodeficiency virus (HIV) infection, hepatitis B, or hepatitis C
  • Are pregnant or breastfeeding

Contact Information

Imran Chaudhary, Study Coordinator
1695 Eastchester Road, Bronx, NY 10461
Phone: (718)- 405-8542
Email: ichaudha@montefiore.org

Advanced Solid Tumors and Pancreatic Cancer

People with advanced solid tumors and pancreatic cancer are asked to participate in a research study being conducted by Northwell Health

You may be eligible to participate in this study if you:

  • Are a male or female at least 18 years of age or older
  • Have histologically confirmed advanced bladder cancer, melanoma, non-small cell lung cancer, pancreatic cancer, colorectal cancer, gastric cancer, esophageal cancer, ovarian cancer, and head neck squamous cell carcinoma

You may not participate in this study if you:

  • Are using a pacemaker, implantable cardiac defibrillator or cochlear implants
  • Have tested positive for Human Immunodeficiency Virus (HIV) Infection
  • Are pregnant, breastfeeding or plan to become pregnant

Contact Information
Sarah Davis, Phase 1 Supervisor
450 Lakeville Road, Lake Success, NY  11042
Phone: (516) 734-7632
Fax: (516) 734-8909
Email: sdavis22@northwell.edu

JAVELIN IL-2 Medley

People with solid tumors are asked to participate in a research study being conducted by Montefiore Medical Center.

You may be eligible to participate in this study if you:

  • Are a male or female at least 18 years of age or older
  • Have histological diagnosis of solid tumors

You may not participate in this study if you:

  • Have known history of: immune-mediated colitis, inflammatory bowel disease, pneumonitis, or pulmonary fibrosis.
  • Have had a live vaccine within the past 4 weeks
  • Have history of immunodeficiency virus (HIV) infection, hepatitis B or hepatitis C
  • Are pregnant or breastfeeding

Contact Information

Imran Chaudhary, Study Coordinator
1695 Eastchester Road, 2st Floor
Bronx, NY 10461
Phone: (718) 405-8542
Fax: (718) 405-8527
Email: ichaudha@montefiore.org
19-06-256 / TX228658

Advanced Solid Tumors

People with solid tumors are asked to participate in a research study being conducted by Montefiore Medical Center.

You may be eligible to participate in this study if you:

  • Are a male or female at least 18 years of age or older
  • Have confirmed locally-advanced (unresectable) or metastatic solid tumor malignancy

You may not participate in this study if you:

  • Have received a live vaccine within the past 28 days
  • Have an active autoimmune disease
  • Have positive Hepatitis B virus antibodies and surface antigen (indicating acute HBV or chronic HBV) or Hepatitis C
  • Are pregnant or breastfeeding

Contact Information

Mohammad Ghalib, Study Coordinator
1695 Eastchester Road, 2nd Floor
Bronx, New York 10461
Phone: (718) 405-8515
Email: mhghalib@montefiore.org

19-06-134 / TX226742

Advanced Solid Tumors

People with advanced solid tumors are asked to participate in a research study being conducted by Northwell Health.

You may be eligible to participate in this study if you:

  • Are a male or female at least 18 years of age or older
  • Have histologic or cytologic confirmation of advanced solid tumor with the exception of ocular melanoma and hepatocellular carcinoma
  • Have received and have progressed on or be refractory to at least 1 line of standard systemic therapy in the recurrent/metastatic setting

You may not participate in this study if you:

  • Have moderate or severe cardiovascular disease
  • Have had major surgery within the past 4 weeks
  • Have known immunodeficiency virus (HIV) infection, active hepatitis B or hepatitis C
  • Are pregnant, breastfeeding or plan to become pregnant

Contact Information

Sarah Davis, Research Manager
450 Lakeville Road
Lake Success, NY 11042
Phone: 516-734-7632
Email:  sdavis22@northwell.edu

 

19-06-090 / TX226751

Solid Tumors

People with solid tumors are asked to participate in a research study being conducted by Icahn School of Medicine at Mount Sinai.

You may be eligible to participate in this study if you:

  • Are a male or female at least 18 years of age, nut not more than 75
  • Have histologically or cytologically documented, locally-advanced or metastatic solid malignancy of any type

You may not participate in this study if you:

  • Have received investigational treatment in another clinical study within the past 4 weeks
  • Have known history of liver disease, including viral or other hepatitis or cirrhosis
  • Have known immunodeficiency virus (HIV) infection
  • Are pregnant or breastfeeding

Contact Information
Jennifer Perez, Study Coordinator
One Gustave L. Levy Place
New York, New York 10029
Phone: (212) 824-7303
Email: jennifer.perez2@mssm.edu