When is IBC review required?

Institutional Biosafety Committee review is required when research involves human gene transfer or the use of recombinant or synthetic nucleic acid molecules and is NIH-funded or conducted at an institution that receives NIH funding. The reach is broad: if even one such project at an institution benefits from NIH support, all recombinant or synthetic nucleic acid research conducted at or sponsored by that institution must comply with the NIH Guidelines and undergo IBC review.